Analytical equipment and technology

Analytical equipment and technology

• Analytical HPLC and UHPLC (e.g. normal phase, RP-, ion pair chromatography), Ph.Eur.
  – isocratic, binary and trivalent high pressure gradient systems
  – column switching
  – cooling sample-compartment
• DAD, UV/Vis-, RI and Fluorescence-detection
• GC / MS equipped with headspace, Ph.Eur.
  – N2 und He as carrier gas
  – FID, MS-detection
• Dissolution tester (e.g. paddle, basket, use of sinker), Ph.Eur.
• Permeation testing by Franz-Cells
• TLC, Ph.Eur.
• Computer-controlled titration (Titrino, e.g. Karl Fischer), Ph.Eur.
• UV/Vis-spektroscopy, Ph.Eur.
• FTIR, Ph.Eur.
• Gel chromatography (SEC), Ph.Eur.
• Potentiometry, Ph.Eur.
• Pharmaceutic-physical investigations
  (e.g. resistance to crushing, friabiltiy, disintegration, weight variation), Ph.Eur.
• Loss on drying, Ph.Eur.
• Determination of sub-visible particles by
  – Light obscureness, Ph.Eur. – Method 1
  – Microscope, Ph.Eur. – Method 2
• Monitoring by light scattering (PCS) of nanoparticles and emulsions for parenteral application
• Sieve analysis, Ph.Eur.
• Bulk density / Tapped density, Ph.Eur.
• Osmolarity, Ph.Eur.
• Viscosity, Ph.Eur.
• Melting point, Ph.Eur.
• Optical rotation, Ph.Eur.
• Refractometry, Ph.Eur.
• Density Ph.Eur.
• Biochemical methods, e.g. Electrophoresis technology, Western Blot, SEC